Fig. 2: Classification of the top ALT- and AST- associated loci based on annotations. | Nature Communications

Fig. 2: Classification of the top ALT- and AST- associated loci based on annotations.

From: GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms

Fig. 2

Unless otherwise noted with an asterisk, loci are named by the closest protein-coding gene. “Coding” indicates that one of the variants linked to the lead variant is predicted to have a moderate or high impact on a protein-coding gene. “Liver eQTL” and “Muscle or kidney eQTL” indicate that one of the variants linked to the lead variant is the strongest eQTL for a gene in those tissues by GTEx. Loci are further categorized as followed: asterisk, indicating the locus is named for a gene other than the closest to the lead variant, due to coding or eQTL annotation; gray, indicating the lead variant is over 100 kilobases from a protein-coding gene; bold, indicating a known GWAS catalog ALT or AST locus; bold and underlined, indicating a known GWAS catalog ALT and AST locus. Source data for this figure are in Supplementary Data 2.

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