Fig. 1: The preparation and mechanism of the artificially engineered macrophages. | Nature Communications

Fig. 1: The preparation and mechanism of the artificially engineered macrophages.

From: Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer

Fig. 1

a Schematic illustration of the preparation of Oxa(IV)@ZnPc@M. b The mechanism of Oxa(IV)@ZnPc@M mediated chemo-photodynamic therapy to trigger robust antitumor immune responses and potentiate PD-L1 blockade immunotherapies for anti-primary and bone metastatic tumors. Photodynamics therapy (PDT), immunogenic cell death (ICD), Dendritic cells (DCs). ① Intravenous injection and tumor distribution of Oxa(IV)@ZnPc@M, ② PDT and chemotherapy of primary tumor to induce ICD and the release of tumor-associated antigens, ③ ④ DCs maturation and antigen presentation, ⑤ ⑥ CTLs traffic to tumors, and ⑦ Inhibition of primary and bone metastatic tumors simultaneously combined with anti-PD-L1.

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