Fig. 1: Schematic representation of strategy. | Nature Communications

Fig. 1: Schematic representation of strategy.

From: Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice

Fig. 1

a Systemic administration of RapaLink-1 (purple) inhibits mTORC1 in the periphery and in the brain. b RapaBlock (pink), a small molecule that does not cross the blood–brain barrier (BBB) (green) and competes with RapaLink-1 (purple) for FKBP12 (yellow) binding in the periphery, protects mTORC1 activity outside of the CNS. Systemic co-administration of RapaLink-1 and RapaBlock allows for brain-specific inhibition of mTORC1.

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