Fig. 7: Plasma cells produce antibodies specific for nucleolar proteins including Ki-67.
From: Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection
a Pie charts showing the frequency of HEp-2-reactive antibodies in indicated patients. b, c HEp-2 staining images of the three antibodies used for the IP/mass spectrometry (b) and their top 10 preferentially bound antigens (c). Log2 fold changes of signal intensity compared with the mean of the two negative control antibodies are shown. The scale bar indicates 50 µm. d Staining images showing signal colocalization between the antinucleolar antibodies and a commercial anti-Ki-67 antibody on human tonsil tissue. Scale bars indicate 50 μm. For (b, d), staining has been repeated twice and a representative result is shown.
