Fig. 1: Binding activity of cross-reactive human mAbs to GI and GII VLPs.
From: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses
An indirect ELISA was used to assess the binding activity of 12 human mAbs to GI.1, GI.2, GI.3, GII.3, GII.4, GII.6, GII.13 or GII.17 VLPs. A Half-maximal effective concentration (EC50) for binding to VLPs of the indicated genotype. Listed are the isotype, light chain, and EC50 value to GI.1, GI.2, GI.3, GII.3, GII.4, GII.6, GII.13, or GII.17 VLPs. The > symbol indicates binding was not detected at the highest concentration tested, 500 nM. Greater EC50 values are in the lightest shade of orange and lowest EC50 values are in the darkest shade of orange. B Representative ELISA binding curves are shown for indicated genotype. The binding curve for NORO-320 IgA, which is studied in detail here, is highlighted. Data presented are means ± SE, n = 2 independent study replicates and from one of two independent experiments with similar results. Source Data are provided.
