Fig. 6: NORO-320 Fab in complex with GII.4 P-domain.
From: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses
A X-ray crystal structure of the NORO-320-GII.4 P-domain complex. The two P-domain subunits in the dimer are colored in blue and green. NORO-320 Fab (yellow-heavy chain and red-light chain) along with two molecules of H-type 1 pentasaccharide (stick model) are modeled to indicate the glycan-binding sites for reference. Depicted are side and top views of the complex. B Side view of NORO-320 in complex with GII.4 P-domain showing the interacting Fab residues (stick model) with the light and heavy chain residues shown in red and yellow, respectively, interacting. C Close-up view of the Fab binding site (black box in B) showing the P-domain residues (stick models) that interact with the Fab. Residues in the two-fold related subunit (green) are hyphenated. D Close-up view of the Fab residues (light chain-red, heavy chain yellow) that interact with the GII.4 P-domain (shown in surface representation).
