Fig. 8: Amino acid sequence alignment of the protruding domain of GI.1, GII.3, GII.4, GII.13, and GII.17 strains of HuNoV.
From: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses
The protruding domain amino acid sequences of GII.3, GII.4, GII.13, and GII.17, the GII strains tested for which NORO-320 exhibited reactivity, and GI.1 are aligned. The 18 residues identified on GII.4 that interact with the highly cross-reactive mAb NORO-320 are boxed in red. The residues previously reported to be involved in GII.4 HBGA binding55 are boxed in gold and blue. The recently identified low-affinity bile acid-binding site56 is boxed in green.
