Fig. 6: Transport mechanism of ABCG2.
From: Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism
Schematic of structure-based, proposed transport cycle of ABCG2. Key states are shown as boxes and numbered. Where available, structures are shown as ribbon diagrams with bound nucleotides and substrates shown as spheres and labeled. Cartoon schematics of the relevant states are drawn to emphasize the conformations of the TMDs and NBDs, identify cavities, indicate the presence of bound drugs, and as well as the state of the leucine gate. Previously determined structures correspond to PDB IDs 5NJ3 (apo-inward) and 6HBU (closed conformation). No structure is available of the proposed outward-open conformation (state 3).
