Fig. 6: Model for Wzc function.
From: The molecular basis of regulation of bacterial capsule assembly by Wzc
Wzc, the master regulator of capsule assembly and export regulates the activity of Wzy (polymerase) and opens Wza (translocon). Multi phosphorylated Wzc is found as a monomer whilst dephosphorylated Wzc forms an octamer. Capsule product and export requires continuous Wzc cycling between phosphorylation and dephosphorylation states. Polymer chain completion may be accomplished in a single or stepwise by multiple cycles.
