Fig. 5: SNc-projecting SC neurons are selectively recruited during appetitive locomotion.
From: The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice
a Schematic diagram showing fiber photometry recording from SNc-projecting SC neurons. b An example micrograph showing optical-fiber track above the SNc-projecting SC neurons that expressed GCaMP7. This experiment was repeated independently in six mice with similar results. c, f Example pictures showing fiber photometry recording from SNc-projecting SC neurons when mice exhibit appetitive locomotion toward prey (c) or defensive locomotion away from looming visual stimuli (f). d, g Time courses of normalized GCaMP fluorescence of SNc-projecting SC neurons of an example mouse before and during appetitive locomotion toward prey (d) or defensive locomotion away from looming visual stimuli (g). e, h Quantitative analyses of GCaMP fluorescence showing the SNc-projecting SC neurons were activated during appetitive locomotion toward prey (e) and inactivated during defensive locomotion away from looming visual stimuli (h). Scale bars are indicated in the graphs. Number of mice was indicated in the graphs (e, h). Data in d, e, g, h are means ± SEM (error bars). Statistical analyses in e, h were performed by one-sided Student’s t-test (***P < 0.001).
