Table 1 Wnk1 knockout is lethal in immortalized macrophages with fully functional NLRP3 inflammasome activity.

From: Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

 

#Clones tested

#WT clones

#Het clones

#KO clones

Wild type

31

27

4

0

Rip1 KO

36

31

5

0

NLRP3 KO

18

10

5

3

Caspase 1 KO

18

14

1

3

ASC KO

36

20

8

8

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