Fig. 2: Rpap3 is necessary to small intestine integrity.
From: The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium
a Schematic representation of the experimental setting: 8-week-old mice of the indicated genotype received two sequential injections of tamoxifen 24 h apart, and were analyzed 6 to 8 days after the first injection. b Pictures of jejunum tissue sections stained with HE (left) or by IHC with anti-Ki67 antibodies (right panels—Ki67 signal is brown) at different days after the first tamoxifen injection. Black arrowheads indicate remnants of crypt glands with Ki67+ cells observed at day 8. Scale bar is identical for all panels, and is 50 μm as shown in control HE panel. Each panel is representative of 8 to 12 animals from three independent experiments.
