Fig. 2: Subpopulation analysis of NK cells and CD8+ T cells. | Nature Communications

Fig. 2: Subpopulation analysis of NK cells and CD8+ T cells.

From: Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets

Fig. 2

a UMAP plot of the NK cell subpopulations in all groups, colored to indicate cluster information. b Proportion of each cell type in NK cell clusters at uninfected control (n = 3), 2 dpi (n = 3), and 5 dpi (n = 4). c Violin plots showing expression levels of STAT1, OAS1, ISG15, GZMB, GZMK, and PRF1 in the five NK cell clusters. d UMAP plot of the CD8+ T-cell subpopulations in all groups, colored to show cluster information. e, f Violin plots showing expression levels of CD69, S1PR1, ITGAE, OAS1, ISG15, IFNG, GZMB, and PRF1 in the four CD8+ T cell clusters. g UMAP plot in which color density reflects the distributions of CD8+ T cells ferrets in the negative control, at 2 dpi and 5 dpi with SARS-CoV-2. The red circle indicates a concentrated area of cluster 0 with CD8+ T cells at 2 dpi, and the blue circle indicates that of CD8+ T cells at 5 dpi. h UMAP plots show normalized expressions of OAS1 and ISG15 in CD8+ T cells. Source data are provided as a Source Data file.

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