Table 1 Neuroplasticity-related proteins regulated by stress-induced secretory autophagy.
From: Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Protein | Fold change | Functions | Related mental disorders |
---|---|---|---|
APP | Neuronal maturation, synaptogenesis, synapse remodeling, neurite outgrowth, synaptic activity, LTP | AD | |
JUN | Detected in WT only | Neuronal differentiation and survival during development, post-traumatic repair, memory formation and addiction Immediate early gene regulated by, rather than regulating, neuronal activity and plasticity | |
VIM | Neuroplasticity and neuroregeneration via uptake of C3bot | AD | |
CDC42 | LTP, memory recall, neuronal maturation, synapse formation | ||
MMP9 | Synaptic remodeling, extracellular cleavage of proteins regulating synaptic plasticity, late phase LTP, learning and memory | SCZ, FXS | |
CCL2 | Spinal plasticity, short-term hippocampal synaptic plasticity, neuronal excitability and synaptic transmission via presynaptic mechanisms | AD, depression | |
EEF2 | Synaptic plasticity, long term facilitation (LTF) and learning via local protein synthesis, key sensor for quality of neurotransmission; | ||
HMGB1 | DAMP molecule, synaptic plasticity via inflammatory signaling | AD | |
IGF1 | Hippocampal neurogenesis, social memory, LTP, age-related synaptic dysfunction | ||
KDR | Detected in WT only | Neurogenesis and cognition mediated by environmental stimuli, hippocampal excitatory synaptic function, plasticity and related emotional learning processes, hippocampal LTP and consolidation of contextual fear memory | |
LRP1 | Neuroregeneration, conductance of neuronal ion channels, NMDA-induced Ca2 influx into neurons, neurotransmission, NMDAR2B expression at the cell surface, synaptic integrity and function via GluA1 trafficking regulation, APP processing | AD | |
PAK1 | Detected in WT only | Inhibitory postsynaptic currents via GABA presynaptic releases, is regulated by cdc42 | AD, FXS, SCZ, HD |
PAK3 | Detected in WT only | Mental retardation protein, synaptic transmission | Intellectual disability |
STMN2 | Axonal remodeling via late phase LTP microtubule turnover and presynaptic remodeling | ||
TF | AMPA receptor trafficking efficiency and synaptic plasticity via its receptor (TFR) | ||
TGFB1 | Synapsin distribution, synaptic depression, neurite outgrowth, LTP and memory | ||
CAT | LTP, learning and memory via regulation of ROS | Depression, PTSD | |
HMOX1 | Neuronal cytokinetics, survival and plasticity via brain sterol/oxysterol metabolism regulation | AD, PD | |
JUNB | GR/MR induced hippocampal plasticity (putative) Immediate early gene regulated by, rather than regulating, neuronal activity and plasticity |