Table 1 Neuroplasticity-related proteins regulated by stress-induced secretory autophagy.

From: Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion

Protein

Fold change

Functions

Related mental disorders

APP

Neuronal maturation, synaptogenesis, synapse remodeling, neurite outgrowth, synaptic activity, LTP

AD

JUN

Detected in WT only

Neuronal differentiation and survival during development, post-traumatic repair, memory formation and addiction

Immediate early gene regulated by, rather than regulating, neuronal activity and plasticity

 

VIM

Neuroplasticity and neuroregeneration via uptake of C3bot

AD

CDC42

LTP, memory recall, neuronal maturation, synapse formation

 

MMP9

Synaptic remodeling, extracellular cleavage of proteins regulating synaptic plasticity, late phase LTP, learning and memory

SCZ, FXS

CCL2

Spinal plasticity, short-term hippocampal synaptic plasticity, neuronal excitability and synaptic transmission via presynaptic mechanisms

AD, depression

EEF2

Synaptic plasticity, long term facilitation (LTF) and learning via local protein synthesis, key sensor for quality of neurotransmission;

 

HMGB1

DAMP molecule, synaptic plasticity via inflammatory signaling

AD

IGF1

Hippocampal neurogenesis, social memory, LTP, age-related synaptic dysfunction

 

KDR

Detected in WT only

Neurogenesis and cognition mediated by environmental stimuli, hippocampal excitatory synaptic function, plasticity and related emotional learning processes, hippocampal LTP and consolidation of contextual fear memory

 

LRP1

Neuroregeneration, conductance of neuronal ion channels, NMDA-induced Ca2 influx into neurons, neurotransmission, NMDAR2B expression at the cell surface, synaptic integrity and function via GluA1 trafficking regulation, APP processing

AD

PAK1

Detected in WT only

Inhibitory postsynaptic currents via GABA presynaptic releases, is regulated by cdc42

AD, FXS, SCZ, HD

PAK3

Detected in WT only

Mental retardation protein, synaptic transmission

Intellectual disability

STMN2

Axonal remodeling via late phase LTP microtubule turnover and presynaptic remodeling

 

TF

AMPA receptor trafficking efficiency and synaptic plasticity via its receptor (TFR)

 

TGFB1

Synapsin distribution, synaptic depression, neurite outgrowth, LTP and memory

 

CAT

LTP, learning and memory via regulation of ROS

Depression, PTSD

HMOX1

Neuronal cytokinetics, survival and plasticity via brain sterol/oxysterol metabolism regulation

AD, PD

JUNB

GR/MR induced hippocampal plasticity (putative)

Immediate early gene regulated by, rather than regulating, neuronal activity and plasticity

 
  1. List of proteins and related functions found to be associated to neuroplasticity in at least five peer-reviewed publications. Bars indicate fold change in secretion of WT over Atg5 KO cells. Underlining indicates proteins also involved in immune response based on GO analysis; italic indicates extracellular function.
  2. References used for this Table are listed in the Supplementary references.
  3. AD Alzheimer’s disease, PD Parkinson’s disease, SCZ schizophrenia, HD Huntington disease, PTSD post-traumatic stress disorder, FXS fragile X syndrome.