Fig. 7: Proposed model integrating key pathways underlying the parasite survival of host fever and artemisinin resistance.
From: The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
All pathways were identified via pooled phenotypic screening. The direction of regulation in response to HS is informed by comparative RNAseq data where available (pink = increased; blue = decreased). Pathways/proteins previously identified as interacting with K13 are indicated (green triangle). Prenylated proteins are indicated with a pink lightning bolt. Proteins without orthologs in rodent malaria parasites (whose hosts are non-febrile) are indicated with a white diamond. FV food vacuole. Modified from Oberstaller et al.59. Source data are provided as a Source Data file.
