Fig. 5: GR C622 contributes to cisplatin resistance through MAST1.
From: Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1
a, b Cell viability and MEK/ERK activity in GR target downregulated KB-3-1 and A2780 cells by GR shRNA (a) or mifepristone (10 μM) (b) in the presence and absence of cisplatin. MEK and ERK activity was assessed by S221 MEK and T202/Y204 ERK phosphorylation. c, d Cell viability and MEK/ERK in GR enhanced KB-3-1 and A2780 cells by GR overexpression (c) or dexamethasone (500 nM) (d) in the presence and absence of cisplatin. e Cell viability of KB-3-1 and A2780 cells carrying GR WT or C622A in response to cisplatin. f Cisplatin IC50 of KB-3-1 and A2780 cells harboring GR WT or C622A. Data are mean ± SD from three independent biological experiments. Error bars represent SD and statistical analyses were performed by one-way ANOVA. Source data are provided as a Source Data file.
