Fig. 6: GR C622 is crucial for cisplatin resistance through MEK-ERK activation but not DNA damage response. | Nature Communications

Fig. 6: GR C622 is crucial for cisplatin resistance through MEK-ERK activation but not DNA damage response.

From: Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1

Fig. 6

a Dose-dependent analyses of cell viability, γH2AX, cisplatin-DNA adduct, MEK and ERK phosphorylation in KB-3-1 and A2780 cells carrying GR WT or C622A upon cisplatin treatment. b, c Representative Western blot of MEK-ERK pathway change in KB-3-1 (b) and A2780 (c) cells carrying GR WT or C622A upon treatment with increasing concentrations of cisplatin. Data are from three independent experiments and mean ± SEM for blot analyses and mean ± SD for others. Source data are provided as a Source Data file.

Back to article page