Fig. 1: Loss of Sun1 extends the longevity of LaminA (Lmna) mutant mice. | Nature Communications

Fig. 1: Loss of Sun1 extends the longevity of LaminA (Lmna) mutant mice.

From: Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy

Fig. 1

A The median postnatal lifespan of the LmnaF/F/ZP3Cre mice in which a conditional (floxed) Lamin A (LmnaF/F) is deleted in all tissues is 17.5 days. On a Sun1–/– background, median longevity is increased to 32.5 days. B When LmnaF/F is deleted specifically and constitutively in hearts by crossing the mice with the αMyHC-Cre line, the LmnaF/FːαMyHC-Cre mice have a median lifespan of 26.5 days. On a Sun1–/– background, these mice live for longer than 6 months. C 3–5-month-old LmnaF/F mice were crossed with the tamoxifen (Tmx) inducible cardiomyocyte-specific Cre Tg(Myh6-Cre/Esr1) (abbreviated to mcm), after a single injection of Tmx the mice die within 3–4 weeks. On a Sun1–/– background, these mice (LmnaF/F:mcm) live for more than 1 year. D LmnaN195K/N195K animals live for 78 days compared to LmnaN195K/N195KSun1–/– which had a median lifespan of 118 days. A–D (****P < 0.0001; **P = 0.0073 Log-rank (Mantel–Cox) test).

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