Fig. 2: Altered gene and protein expression profiles indicate altered calcium signaling and regulation in VDAC2-KO. | Nature Communications

Fig. 2: Altered gene and protein expression profiles indicate altered calcium signaling and regulation in VDAC2-KO.

From: Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis

Fig. 2

a, b Differential gene expression data derived from 16-week old cardiac ventricular tissue (n = 4); c–f Western blot image of PLN (p = 0.0042), pPLN (p = 0.0045), and NCX (p = 0.0121) along with lane-loading control GAPDH and respective quantification using Image Studio Lite (version 5.2.5) (n = 6); g, h Western blot image of PKA and pPKA and quantification using Image Studio Lite (version 5.2.5) (p = ns) (n = 6); i, j Western blot image of CASQ2 and lane-loading control GAPDH and respective quantification using Image Studio Lite (version 5.2.5) (p = 0.0111) (n = 6); k, l Western blot image of SERCA2 and lane-loading control VINCULIN and quantification using Image Studio Lite (version 5.2.5) (Mann–Whitney: p = 0.0260) (n = 6); m, n Western blot image of RYR2 and lane-loading control VINCULIN and quantification using Image Studio Lite (version 5.2.5) (p = 0.0018) (n = 6). p-value: unpaired two-tailed t-test and two-tailed Mann–Whitney test performed. Data are represented as mean ± SEM.

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