Fig. 8: Stability of AβOs formed by Aβ42 at endo-lysosomal pH after shifting to neutral pH. | Nature Communications

Fig. 8: Stability of AβOs formed by Aβ42 at endo-lysosomal pH after shifting to neutral pH.

From: Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting

Fig. 8

a AFM images of AβOs formed by 10 µM Aβ42 at pH 4.5 before (left) and after (right) shift to pH 7.2. Red arrowheads point to a few of the sites where AβOs seem to detach from AβO clusters. In all, 3–7 micrographs were recorded per condition to ensure reproducibility. b, c Height profiles of small AβOs after pH shift to neutral pH. Height profiles in c correspond to the sections in b. d, e Height profiles of AβOs formed by 110 µM Aβ42 at pH 7.2. Height profiles in e correspond to the sections in d.

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