Fig. 3: Topological insulation of developmental regulators.
From: Topological isolation of developmental regulators in mammalian genomes
a Gene Ontology (GO) enrichment of TIGs in HUES64 shows developmental processes as top terms. b Enrichment of developmental regulators in single-gene CTCF loop domains. The left panel represents the percentage of all genes (AG) or developmental regulators (DR) located within domains. The right panel represents the percentage of AG or DR located within domains containing an increasing number of protein-coding genes. P-values calculated by two-sided Fisher’s exact test. c Evolutionary conservation of consensus CTCF motifs at boundaries of single-gene, multi-gene, and zero-gene CTCF loop domains and nonboundaries. Nonboundary CTCF motifs represent the motifs that are outside of any domain boundaries. The motif region is shown in the box and the motif sequence is displayed. The average conservation score across placental mammals across all boundary regions is shown. The shaded area indicates the standard error. Two-sided Wilcoxon test p-value tested in the motif regions is shown. Data are presented as mean values ± SE. d Evolutionary conservation of consensus CTCF motifs at DR boundaries and non-DR boundaries. See more descriptions in c. Data are presented as mean values ± SE.
