Fig. 4: Disease enrichments in MIS-C modules and cyan.

Slices are modules and each circular row represents the corresponding disease signature defined in the legend on the right. The purple outer rim of the plot represents the sum of the OR for all enrichments in that slice (performed using Fisher’s test). Each slice is divided into two components that show the OR for the enrichment of genes with ±log(fold change) in the corresponding disease signature (red and blue, respectively, as defined in legend). Numbers in the category slice map the circular rows to disease signatures. ORs are shown for disease signature enrichment adjusted p-values < 0.05. Diseases were grouped in biologically meaningful clusters as defined in the legend. Parenthesis in the legend refers to the source of the signature and the tissue or cell type assessed. References for disease signatures are defined in the “Methods” section and all enrichments can be found in Supplementary Data 15.