Fig. 10: Model by which N protein induces lung injury by activating NLRP3 inflammasome. | Nature Communications

Fig. 10: Model by which N protein induces lung injury by activating NLRP3 inflammasome.

From: SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Fig. 10

During SARS-CoV-2 infection, the nucleocapsid protein (N) could directly interact with NLRP3 to promote the assembly and activation of NLRP3 inflammasome, thus leading to the production of a large number of inflammatory factors (such as IL-1β, IL-6, TNF, CCL2, and CCL8) and the occurrence of lung injury in mice.

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