Table 3 Embryo loss during development.

From: Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging

Genotype

Pregs

CL (Avg)

Embryos (Avg)

% embryo loss

WT

6

59 (9.8)

57 (9.5)

3.4

Mlh1E268G

6

58 (9.7)

38 (6.3)

34.5

Mlh1K618E

3

37 (12.3)

29 (9.7)

21.6

Mlh1K618T

5

46 (9.2)

39 (7.8)

15.2

Mlh1V326A

4

35 (8.8)

31 (7.8)

11.4

Mlh1V716M

3

33 (11)

23 (7.7)

30.3

  1. All mutant genotypes are homozygous. Pregs pregnancies dissected, CL Corpora lutea, Avg average. The embryos counted were viable when dissected at E13.5. The % embryo loss = (#CL-#embryos)/#CL * 100.
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