Fig. 6: Endothelial cells show subtype and time specific activation of cytokines.
From: Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19
a Uniform manifold approximation and projection (UMAP) plot of lung endothelial cell subpopulations. Clusters defined by Louvain clustering, n = 3 per time point. Colors representing individual cell types are depicted in legend. b Dotplot of differentially expressed genes in lung endothelial cell subpopulations over time. Shown are genes that are in at least one cell type among the top 10 most changing genes as ranked by adjusted (adj.) p-value. Adjusted (adj.) p-values were calculated by DEseq2 using Benjamini–Hochberg corrections of two-sided Wald test p-values. c Dotplot of differentially expressed genes from two sets (upper set: cytokine/inflammatory mediators; lower set: endothelial/stress/mitosis/apoptosis factors) as indicated in lung endothelial cell subpopulations over time pi. For both b, c coloration and point size indicate log2-transformed fold changes and p-values, respectively, of genes at 2 days post infection (dpi) relative to control groups (naive). Adjusted (adj.) p-values were calculated by DEseq2 using Benjamini–Hochberg corrections of two-sided Wald test p-values.
