Table 2 Rh1/PNP-ND catalyzed hydroformylation of substituted vinyl arenes.
Entry | Substrate | Conv. (%) | Sel.aCHO (%) | b/lb |
|---|---|---|---|---|
1 | 2-methylstyrene | >99 | 99 | 7.3:1 |
2 | 3-methylstyrene | >99 | 99 | 6.9:1 |
3 | 4-methylstyrene | >99 | 99 | 6.7:1 |
4 | 4-tert-butylstyrene | >99 | 99 | 8.8:1 |
5 | 2,5-dimethylstyrene | >99 | 99 | 7.8:1 |
6 | 4-methoxystyrene | >99 | 99 | 7.5:1 |
7 | 3,4-dimethoxystyrene | >99 | 99 | 8.1:1 |
8 | 2-fluorostyrene | 68 | 99 | 10.1:1 |
9 | 3-fluorostyrene | >99 | 98 | 13.3:1 |
10 | 4-fluorostyrene | >99 | 99 | 10.2:1 |
11 | 2-chlorostyrene | 44 | 99 | 11.5:1 |
(>99)c | (99) | (13.3:1) | ||
12 | 3-chlorostyrene | >99 | 99 | 15.7:1 |
13 | 4-chlorostyrene | >99 | 99 | 10.1:1 |
14 | 2-bromostyrene | >99c | 96 | 13.7:1 |
15 | 3-bromostyrene | >99c | 95 | 13.6:1 |
16 | 4-bromostyrene | >99c | 98 | 11.5:1 |
18 | 4-hydroxystyrene | >99 | 99 | 7.9:1 |
19d | 2-vinylnaphthalene | 98 | 99 | 6.2:1 |
