Table 1 Characteristics of the studies included in the analyses.
Study | Ref. | Study site | No. of samples | Variable | Groups | Technique | DEG method | DEGs (n) |
|---|---|---|---|---|---|---|---|---|
Almelli et al. 2014 | Cameroon | 214 | Severity/parasitemia | Asymptomatic vs cerebral malaria | Microarray | Limma package | 234 | |
Andrade et al. 2020 | Mali | 24 | Seasonality/severity/ parasitaemia | Dry asymptomatic vs Wet season mild malaria | RNAseq | DESeq2 | 1609 | |
Cordy et al. 2019 | NA (lab P. coatneyi) | 4 | Disease phase/parasitaemia | Acute vs post-subRx vs chronic | RNAseq | DESeq2 | Not reported | |
Daily et al. 2007 | Senegal and Benin | 43 | NMF clustering of expression profiles | Clusters 1 vs 2 vs 3 | Microarray | GSEA-Gene Set | Not reported | |
Lee et al. 2018 | The Gambia | 46 | Severity/parasite biomass | Severe vs uncomplicated | RNAseq | EdgeR | 236 | |
Lemieux et al. 2009 | The Gambia | 17 | Severity/parasitaemia | Mild vs severe | Microarray | not specified | 278 | |
Milner et al. 2012 | Malawi | 58 | Parasitaemia/severity (CM) | High vs low parasitemia | Microarray | GenePattern | 2774 | |
Rono et al. 2017 | Kenya and Sudan | 96 | Transmission intensity | High vs low transmission settings | Microarray | Limma package | 436 | |
Tonkin-Hill et al. 2018 | Indonesia | 44 | Severity/parasitaemia | Severe vs non-severe | RNAseq | DESeq2 | 358 | |
Yamagishi et al. 2014 | Indonesia | 116 | Severity/parasitaemia | Mild vs severe | RNAseq | Not specified | Not reported |
