Table 2 Individual associations of miR-score, ERS and PRS with CRC incidence in prospective set participants with all scores available (Ncases/controls = 181/174).

From: A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction

Population

Quintilea

Cases

Controls

Model 1b

Model 2c

OR (95% CI)d

P valued

OR (95% CI)d

P valued

miR-score

Q1 (< −1.38]

6 (3.3)

36 (20.7)

0.33 (0.12–0.95)

0.0388

0.34 (0.12–0.97)

0.0439

Q2 (−1.38, −0.91]

14 (7.7)

34 (19.5)

0.82 (0.35–1.93)

0.6552

0.88 (0.37–2.10)

0.7759

Q3 (−0.91, −0.41]

17 (9.4)

34 (19.5)

Ref.

 

Ref.

 

Q4 (−0.41, 0.06]

18 (9.9)

35 (20.1)

1.03 (0.46–2.32)

0.9459

1.09 (0.48–2.50)

0.8352

Q5 (> 0.06)

126 (69.6)

35 (20.1)

7.20 (3.60–14.39)

2.28E-08

7.20 (3.56–14.59)

4.19E-08

ERS

Q1 (<3]

34 (18.8)

42 (24.1)

0.83 (0.44–1.59)

0.580

–

–

Q2 (3, 4]

30 (16.6)

34 (19.5)

0.91 (0.46–1.78)

0.779

–

–

Q3 (4, 5]

35 (19.3)

36 (20.7)

Ref.

 

–

–

Q4 (5, 7]

46 (25.4)

34 (19.5)

1.39 (0.73–2.65)

0.314

–

–

Q5 (>7)

36 (19.9)

28 (16.1)

1.32 (0.67–2.61)

0.419

–

–

PRS

Q1 (<7.66]

16 (8.8)

35 (20.1)

0.46 (0.21–0.97)

0.042

0.49 (0.22–1.05)

0.0680

Q2 (7.66, 7.92]

24 (13.3)

34 (19.5)

0.71 (0.35–1.42)

0.331

0.76 (0.37–1.56)

0.4543

Q3 (7.92, 8.15]

35 (19.3)

35 (20.1)

Ref.

 

Ref.

 

Q4 (8.15, 8.46]

47 (26.0)

35 (20.1)

1.34 (0.71–2.55)

0.367

1.24 (0.64–2.40)

0.5250

Q5 (>8.46)

59 (32.6)

35 (20.1)

1.69 (0.90–3.16)

0.103

1.75 (0.92–3.34)

0.0880

  1. miR-score microRNA risk score, ERS environmental risk score, PRS polygenic risk score, CRC colorectal cancer, OR odds ratio, CI confidence interval, Q quintile, Ref. reference category.
  2. aQuintiles of risk score among controls.
  3. bModel 1: without adjustment for any confounders.
  4. cModel 2: like model 1, adjusted for age and sex.
  5. dOR, 95% CI and two-sided P values were generated from logistic regression model.
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