Table 3 Risk prediction by individual and combined risk scores for CRC.

From: A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction

Population

Predictor

AUC (95% CI)

Brier score

Prospective set (Ncases/controls = 198/178)

miR-score

Apparent: 0.808 (0.765–0.851); 0.632+: 0.794

Apparent: 0.175; 0.632+: 0.184

Prospective set participants with all scores available (Ncases/controls = 181/174)

ERS

0.557 (0.498–0.616)

0.248

PRS

0.622 (0.564–0.681)

0.240

ERS + PRS

0.631 (0.573–0.689)

0.238

miR-score

Apparent: 0.815 (0.771–0.859); 0.632+: 0.802

Apparent: 0.172; 0.632+: 0.181

ERS + miR-score

Apparent: 0.815 (0.771–0.859); 0.632+: 0.814

Apparent: 0.172; 0.632+: 0.174

PRS + miR-score

Apparent: 0.824 (0.782–0.867); 0.632+: 0.822

Apparent: 0.169; 0.632+: 0.171

ERS + PRS + miR-score

Apparent: 0.824 (0.781–0.867); 0.632+: 0.820

Apparent: 0.169; 0.632+: 0.172

  1. miR-score microRNA risk score, ERS environmental risk score, PRS polygenic risk score, CRC colorectal cancer, AUC area under the receiver-operating-characteristic curve, CI confidence interval.
  2. Note– miR-score was derived in the overall prospective set (Ncases/controls = 198/178).
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