Fig. 2: Focused classification of conformational heterogeneity.
From: CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin
a Single ring-focused classification into ten classes. The ring class outlined in black is selected for further analysis in (b). b Subunit-focused classification into ten classes of individual subunits. The subunit classes outlined in a black box are selected for modeling in (c). c Fitted models for corresponding subunit maps shown in (b). The distal tip of the apical domain moves inwards ~35 Å between the most open conformation (class 1) and the most closed conformation (class 8) (shown in the far right model with class 1 and 8).
