Fig. 6: Gene signatures derived from single-nuclei sequencing and spatial transcriptomics outperforms bulk-RNA sequencing-based consensus classifiers in predicting response to immune checkpoint therapy. | Nature Communications

Fig. 6: Gene signatures derived from single-nuclei sequencing and spatial transcriptomics outperforms bulk-RNA sequencing-based consensus classifiers in predicting response to immune checkpoint therapy.

From: An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

Fig. 6

a Association of snSeq/Visium-derived signature scores, or consensus MIBC subtypes, with RECIST v1.1 response in IMvigor 210 Cohort 2 (N = 298, Fisher exact test). b Flow chart for incorporating a CDH12 score into clinical decision making for treatment-naïve and chemoresistant tumors.

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