Table 2 Mendelian randomization studies of the estimated causal associations of circulating RSPO3 level on fractures and bone parameters.

From: RSPO3 is important for trabecular bone and fracture risk in mice and humans

 

rs3734626

rs2489623

Fractures

OR

95% CI

P value

OR

95% CI

P value

 Fracture at any bone site

0.83

(0.80–0.86)

1.6E−20

0.83

(0.79–0.87)

9.0E−15

 Distal forearm fractures

0.70

(0.70–0.78)

2.4E−12

0.65

(0.57–0.73)

8.5E−13

 Hip fractures

0.84

(0.74–0.97)

1.4E−02

0.88

(0.74–1.03)

1.1E−01

Bone parameters

Beta

SE

P value

Beta

SE

P value

 eBMD

0.21

0.01

2.2E−307

0.23

0.01

1.8E−243

 Trabecular vBMD

0.28

0.09

9.4E−04

0.31

0.10

2.5E−03

 Cortical vBMD

−0.03

0.05

5.0E−01

0.07

0.06

2.1E−01

 Cortical thickness

0.05

0.05

3.7E−01

0.06

0.06

3.4E−01

  1. Inverse variance-weighted (IVW) Mendelian randomization of the estimated causal association of circulating RSPO3 on fractures and bone parameters using rs3734626 (left part) or rs2489623 (right part) as a genetic instrument. Betas in SD (or ORs) are given per SD increase in circulating RSPO3. eBMD = estimated bone mineral density measured by ultrasound in the heel. Trabecular vBMD = Trabecular volumetric BMD as measured by pQCT in the distal tibia metaphysis. Cortical vBMD = Cortical volumetric BMD as measured by pQCT in the tibia diaphysis. Cortical thickness = Cortical thickness measured by pQCT in the diaphysis of tibia. Genetic associations with the exposure (RSPO3) and outcomes (fractures and bone parameter) used in the Mendelian randomization are presented in Table 1b (rs3734626) and Table 1c (rs2489623).The statistical tests were two-sided. No adjustments were made for multiple comparisons.
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