Fig. 1: Ni-catalyzed syntheses of vinyl C-glycosyl amino acids and peptides. | Nature Communications

Fig. 1: Ni-catalyzed syntheses of vinyl C-glycosyl amino acids and peptides.

From: Facile access to C-glycosyl amino acids and peptides via Ni-catalyzed reductive hydroglycosylation of alkynes

Fig. 1

a The N-linked core Man3GlcNAc2β1-Asn motif in glycoproteins, the O-linked tumor-associated carbohydrate antigen Sialyl Lewisx in glycolipids, and the native N/O/C-glycosidic linkages in glycoproteins. b Nickel-catalyzed reductive hydroglycosylation for access to vinyl C-glycopeptides and a plausible mechanism. c Structure of the glycosyl donors 1 and potential by-products 4 and 5. The glycosidic bonds are highlighted in red.

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