Fig. 4: Negative selection is associated with AML-free survival.
From: Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood
a Kaplan–Meier curves of AML-free survival among EPIC participants. Survival is defined as the time between blood sample collection and diagnosis (for cases), for control survival is right-censored at last follow-up. Survival curves are stratified according to evolutionary class (positive = green, negative = red, combination = orange, neutral = blue). b Forest Plot of risk of AML development across evolutionary classes. Each row indicates hazard ratios associated with each evolutionary class (reference = neutral class). The horizontal lines indicate a 95% confidence interval for each class.
