Fig. 1: Distribution of CD4 T cell lineage and phosphoprotein signaling profiles in non-ICU and ICU COVID-19 patients.
From: The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients
a Frequencies of Th1 (CXCR3+T-bet+), Th2 (CCR4+Gata-3+), Th17 (CCR6+RoR-γt+) and Treg (CD25+CD127-FoxP3+) CD4 T cell sub-populations in healthy subjects (N = 146), non-ICU (N = 50) and ICU (N = 25) patients. b Mean signal intensity of ex vivo phospho-STAT1 (pSTAT1), pSTAT3, pSTAT5, p38, pMAPKAP2, pNFkB, pCREB, pS6 and pERK1/2 in healthy subjects (N = 39), non-ICU (N = 33) and ICU (N = 29) patients. Blue plots correspond to healthy subjects (H.S), red plots correspond to non-ICU patients and green plots correspond to ICU patients. Black stars indicate statistical significance between ICU or non-ICU patients and healthy subjects. Statistical significance (P values) was obtained using two-sided Kruskal–Wallis test, using a Bonferroni correction. *P < 0.05; **P < 0.01; ***P < 0.001. Exact P values are available in Source Data file.
