Table 1 Performance (area under the receiver-operating curve (AUC), sensitivity, specificity, positive and negative predictive values, and likelihood ratio) of each candidate markers dichotomized into lower than, higher, or equal to the cutpoint distinguishing ICU and non-ICU COVID-19 patients of the discovery cohort.
From: The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients
Marker | Cutpoint | AUC | Sensitivity | Specificity | Positive predictive value | Negative predictive value | Likelihood ratio |
|---|---|---|---|---|---|---|---|
HGF | 593.1 | 0.911 (0.854–0.969) | 88.6 (75.4–96.2) | 81.5 (68.6–90.7) | 79.6 (65.7–89.8) | 98.9 (98.6–99.2) | 4.79 (2.71–8.46) |
CXCL13 | 119.7 | 0.875 (0.801–0.948) | 88.6 (75.4–96.2) | 79.6 (66.5–89.4) | 78.0 (64.0–88.5) | 89.6 (77.3–96.5) | 4.35 (2.54–7.45) |
CXCL9 | 19 | 0.869 (0.801–0.936) | 84.1 (69.9–93.4) | 74.1 (60.3–85.0) | 72.5 (58.3–84.1) | 85.1 (71.7–93.8) | 3.24 (2.03–5.18) |
IL-6 | 25.6 | 0.796 (0.708–0.884) | 77.3 (62.2–88.5) | 79.6 (66.5–89.4) | 75.6 (60.5–87.1) | 81.1 (68.0–90.6) | 3.79 (2.19–6.58) |
CCL2 | 121.3 | 0.775 (0.676–0.873) | 65.9 (50.1–79.5) | 85.2 (72.9–93.4) | 78.4 (61.8–90.2) | 75.4 (62.7–85.5) | 4.45 (2.27–8.73) |
CXCL10 | 156 | 0.743 (0.640–0.846) | 68.2 (52.4–81.4) | 75.9 (62.4–86.5) | 69.8 (53.9–82.8) | 74.5 (61.0–85.3) | 2.83 (1.69–4.74) |
IL-1RA | 2741.7 | 0.734 (0.635–0.833) | 79.5 (64.7–90.2) | 61.1 (46.9–74.1) | 62.5 (48.5–75.1) | 78.6 (63.2–89.7) | 2.05 (1.42–2.95) |
CCL4 | 40 | 0.714 (0.611–0.818) | 79.5 (64.7–90.2) | 59.3 (45.0–72.4) | 61.4 (47.6–74.0) | 78.0 (62.4–89.4) | 1.95 (1.37–2.78) |
VEGF-A | 677.4 | 0.702 (0.597–0.807) | 61.4 (45.5–75.6) | 77.8 (64.4–88.0) | 69.2 (52.4–83.0) | 71.2 (57.9–82.2) | 2.76 (1.59–4.79) |
IL-15 | 16.2 | 0.689 (0.581–0.796) | 65.9 (50.1–79.5) | 72.2 (58.4–83.5) | 65.9 (50.1–79.5) | 72.2 (58.4–83.5) | 2.37 (1.47–3.83) |
IL-10 | 3.1 | 0.687 (0.599–0.775) | 50.0 (34.6–65.4) | 88.9 (77.4–95.8) | 78.6 (59.0–91.7) | 68.6 (56.4–79.1) | 4.50 (2.00–10.1) |
IL-1β | 4.325 | 0.690 (0.582–0.797) | 69.8 (53.9–82.8) | 70.9 (57.1–82.4) | 65.2 (49.8–78.6) | 75 (61.1–86.0) | 2.4 (1.5–3.8) |
LIF | 15.23 | 0.703 (0.597–0.809) | 65.1 (49.1–79.0) | 72.7 (59.0–83.9) | 65.1 (49.1–79.0) | 72.7 (59.0–83.9) | 2.4 (1.5–3.9) |
