Fig. 1: Progression of human NAFLD to cirrhosis and HCC correlates with an increase of eIF6 that counteracts a drop of ribosomal proteins. | Nature Communications

Fig. 1: Progression of human NAFLD to cirrhosis and HCC correlates with an increase of eIF6 that counteracts a drop of ribosomal proteins.

From: Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma

Fig. 1

a Data-mining studies, in NAFLD patients, reveal an increase in eukaryotic Initiation Factor 6 mRNA and a concomitant reduction of expression of genes encoding for ribosomal proteins (rpL; rpS) and initiation factors (eIFs). Two-tailed t test. Data are presented as mean ± SEM. b, c Representative H&E and IHC staining on human liver sections show a reduction of rpS6 phosphorylation (left) and overexpression of eIF6 (right) during NAFLD progression. Scale bars = 50 µm. d Quantification of eIF6 and PS6 (phosphorylated rpS6) signals in mild, moderate, and severe steatosis. Data are presented as mean ± SD. ****p value ≤ 0.0001. N = 12/class. Two-tailed t test. e Violin plots showing the expression levels of eIF6 in healthy (gray) and cirrhotic (purple) livers. Black lines denote the median. Retrieved from single-cell RNA-seq22. f KM survival curves of primary liver cancer patients stratified for eIF6 mRNA levels. Data are retrieved from The Human Pathology Atlas54. Log-rank P value was used for statistical significance. Hazard ratio = 1.970; 95% confidence interval of ratio = 1.374 to 2.824. g Expression levels of eIF6 in primary tumors of metastatic liver cancer, compared with not metastatic. Data are presented as mean ± SEM. Two-tailed t test. NAFLD nonalcoholic fatty liver disease, HCC hepatocellular carcinoma. Data are provided as a Source Data File.

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