Fig. 4: eIF6 haploinsufficiency affects hepatic lipogenesis. | Nature Communications

Fig. 4: eIF6 haploinsufficiency affects hepatic lipogenesis.

From: Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma

Fig. 4

a Heatmap of differentially expressed genes in eIF6+/− versus eIF6+/+ livers: each column represents a single liver sample. Read count differences are visualized as Z-scores. Genes are clustered in four indicated biological processes. b–d Real-Time PCR analysis of selected targets validates RNA-Seq data (n = 3 for genotype). Data are represented as means ± SD. Two-tailed t test. **p value ≤ 0.01, ***p value ≤ 0.001. Data are provided as a Source Data File.

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