Fig. 2: Synthetic route of hypoxia-responsive amphiphilic dendrimer (HAD).
From: An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination
a–c A 2-nitroimidazole derivative and a polylysine dendron were synthesised as the hydrophobic and hydrophilic parts of HAD, then the two parts were conjugated through readily click chemistry to obtain the amphiphilic dendrimer. The synthetic route of the hydrophobic part of HAD (a), the synthetic route of the hydrophilic part of HAD (b) and the synthetic route of HAD (c) were shown.
