Fig. 3: Substrates scope of o-QMs.
From: Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman
Unless otherwise noted, all reactions were carried out on a 0.2 mmol scale with 1.0 eq precursor of o-QMs 2, 1.2 eq 3a, 10 mol% of Sc(OTf)3, 11 mol% of L-PiMe2t-Bu and 5 mol% of JohnphosAu in DCM (2.0 mL) under 6 °C. Isolated yield for major diastereomer. ee was determined by chiral HPLC. D.r. was detected by crude 1H-NMR.
