Fig. 4: Substrates scope of α-propargyl benzyl alcohols.
From: Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman
Unless otherwise noted, all reactions were carried out on a 0.2 mmol scale with 1 eq 2h, 1.2 eq 3, 10 mol% of Sc(OTf)3, 11 mol% of L-PiMe2t-Bu and 5 mol% of JohnphosAu in DCM (2.0 mL) under 6 °C. Isolated yield for major diastereomer. ee was determined by chiral HPLC. D.r. was detected by crude 1H-NMR. a11 mol% of L-PiAd as ligand.
