Table 2 A normalisation method abbreviation dictionary.

From: A hierarchical approach to removal of unwanted variation for large-scale metabolomics data

Tags

Definition

X_Y

Methods separated by ‘_’ indicates 2 levels of adjustments applied. In this example, X is the intra-batch adjustment applied and Y indicates the inter-batch adjustment method applied

X+Y

Methods separated by ‘+’ denotes a method Y implemented in an R package X

loess

A loess line fitting method with pooled QC samples

rlm

A robust linear model fitted to pooled QC samples

loessSample

A loess line fitting method only on biological samples

rlmSample

A robust linear model fitted only on biological samples

short

RUV with short (intra-batch) sample replicates

batch

RUV with batch (inter-batch) sample replicates

_H

A hierarchical balanced tree approach

_Hc

A hierarchical concatenating tree approach