Fig. 1: Sensitivity of HTLV-1 integrase to different classes of integrase strand transfer inhibitors (INSTIs) in vitro. | Nature Communications

Fig. 1: Sensitivity of HTLV-1 integrase to different classes of integrase strand transfer inhibitors (INSTIs) in vitro.

From: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Fig. 1

a Screening of HTLV-1 IN strand transfer activity in presence of a panel of INSTIs at 634 nM. Results are shown from high to low inhibition activity within each colour-coded INSTI class. Percent inhibition compared with WT HTLV-1 IN in the presence of a vehicle is shown. b IC50 values were determined for the most promising INSTIs from the naphthyridine and pyridinone classes and compared with previously obtained raltegravir (RAL) and bictegravir (BIC) values9. c EC50 values for INSTIs tested in the MT-2–Jurkat cell-to-cell infection model and compared with previously reported RAL and BIC values9. Individual data points, mean values and standard deviations of n = three biologically independent experiments are shown. Exact IC50 and EC50 values are contained in Supplementary Figs. 4 and 5 and Supplementary Table 2. Source data are provided as a Source Data File.

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