Fig. 2: Structures of the INSTIs and the STLV-1 Intasome. | Nature Communications

Fig. 2: Structures of the INSTIs and the STLV-1 Intasome.

From: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Fig. 2

Chemical structures of the INSTIs used in the structural studies of binding to the deltaretroviral intasome: a Raltegravir. b Bictegravir. c XZ450. Most frequently substituted positions 4 and 6 are indicated with yellow and pink circles, respectively. d–e Overall structure of the STLV-1 intasome: RAL complex solved by cryo-EM. Each colour represents an independent integrase (IN, grey, dark blue, indigo and violet) and B56 (light and dark green) chain. Viral DNA (vDNA) is coloured light blue. Active site regions are marked with white rectangles.

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