Fig. 3: Close-up of the active site of STLV-1 intasome (red) in a complex with RAL (grey). | Nature Communications

Fig. 3: Close-up of the active site of STLV-1 intasome (red) in a complex with RAL (grey).

From: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Fig. 3

a–b Overall structure of the complex with the cryo-EM map (cyan) overlaid. Magnesium ions are shown as green spheres. c–d Superposition of the STLV-1 intasome:RAL complex (red) on the previously reported apo form of the STLV-1 intasome (PDB ID: 6Z2Y; blue). The DNA of the intasome:apo structure is shown in gold. RAL is shown as sticks with the carbon atoms in grey. dA, deoxyadenosine; dC, deoxycytidine; RAL, raltegravir.

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