Fig. 4: STLV-1 intasome:INSTI complex structures. | Nature Communications

Fig. 4: STLV-1 intasome:INSTI complex structures.

From: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Fig. 4

a View of the active site with the three INSTI structures overlaid binding to the STLV-1 intasome. Magnesium ions are coloured green. For clarity, the true positioning of the INSTIs is shown in the context of the intasome:RAL complex structure only (grey) which is shown in surface view (a) and sticks (b). c–e Active sites of all three complete intasome:INSTI complex structures are shown in cartoon with side chains as sticks. Magnesium ions are coloured according to the colour of the rest of the model. The drugs are shown as sticks, with the carbon atoms of RAL in magenta, BIC in purple and XZ450 in cyan. dA, deoxyadenosine; dC, deoxycytidine; RAL, raltegravir; BIC, bictegravir.

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