Fig. 5: Similarities to other retroviral intasome:INSTI complexes. | Nature Communications

Fig. 5: Similarities to other retroviral intasome:INSTI complexes.

From: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Fig. 5

Comparison between the mode of binding of RAL (a), BIC (b) and naphthyridine-based INSTIs XZ450 and XZ419 (c) to STLV-1 and HIV-1/PFV intasomes. The inset in a shows a significant shift in the position of STLV-1 residue Y149 (not visible in the original panel). PFV and STLV-1 IN have 35.8% sequence similarity, RMSD calculations comparing active sites were calculated as described in the Methods. For PFV intasome:RAL versus STLV-1 intasome:RAL the RMSD within the active site is 1.680 Å (214 atoms to 214 atoms). b HIV-1 and STLV-1 display 40.43% sequence similarity, RMSD within the active site between the HIV-1 intasome:BIC and STLV-1 intasome:BIC structures is 4.516 Å (238 atoms to 238 atoms). c RMSD within the active site for HIV-1 intasome:XZ419 versus STLV-1 intasome:XZ450 is 2.122 Å (228 atoms to 228 atoms). The following PDB models were used: 3OYA (a), 6PUW (b) and 6V3K (c). Superpositions were conducted by the align function in PyMOL and adjusted manually if needed. dC, deoxycytidine; PFV, prototype foamy virus; RAL, raltegravir; BIC, bictegravir.

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