Fig. 4: ROS generation in deep tissue.
From: A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
a The fluorescence imaging of 4T1 tumor-bearing nude mice with i.t. injection of SOSG and [Ru(bpy)3]2+ for varied US irradiation durations. The tumor tissue position is pointed out by red circle. b The fluorescence imaging to investigate 1O2 generation in the presence of [Ru(bpy)3]2+ and SOSG in deep pork tissue (>10 cm) under 30 min US irradiation. SOSG and [Ru(bpy)3]2+ mixing solution was injected at different distances (every 2 cm position) from the US probe into pork. c The fluorescence imaging of DAPI (blue) and DCFH-DA (green) co-stained tumor slices collected from mice after different treatments. Ru: [Ru(bpy)3]2+; US: 0.3 W cm−2, 3 MHz.
