Fig. 5: In vivo sonotherapy.
From: A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy
a Schematic of the in vivo sonotherapy procedure in 4T1 tumor-bearing mice. Mice was irradiated by US (0.1, 0.2, 0.3 W cm−2, 3 MHz) for 20 min after 4 h i.t. injected with [Ru(bpy)3]2+ solution. Tumor sizes were monitored every two days for 14 days in total. b Tumor growth curves of mice after various treatments. Error bars were standard errors (±SD) based on five mice in each group. Statistical significance was calculated with two-tailed Student’s t test, p = 0.000092 (***p < 0.001, **p < 0.01, or *p < 0.05). c Representative images of mice at day 14 after various treatments. d Average tumor weights of mice at 14 day post various treatments as shown in (e). e Photos of tumors were collected from mice at 14 day after various treatments. Ru: [Ru(bpy)3]2+. Error bars were standard errors based on five mice in each group. Statistical significance was calculated with two-tailed Student’s t test, p = 0.00023 (***p < 0.001, **p < 0.01, or *p < 0.05).
