Fig. 3: Enhanced resting-state, but suppressed target-induced, oscillations in the Shank2–/– mPFC. | Nature Communications

Fig. 3: Enhanced resting-state, but suppressed target-induced, oscillations in the Shank2–/– mPFC.

From: Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

Fig. 3

a Enhanced resting-state, but suppressed target (S/O/E combined)-induced, oscillations in the Shank2–/– mPFC compared with WT mice. Local field potentials (LFPs) measured during rest periods and the entire period of S/O/E target exploration were used for the analysis (n = 53 experiments from 5 WT mice, and 52 experiments from 5 KO mice, *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant, two-way ANOVA with Tukey’s test; genotype p < 0.001, event p = 0.153, interaction p = 0.712 [delta], rest p = 0.014, target WT-KO p < 0.001 [WT-KO-delta], WT p > 0.05, KO p > 0.05 [rest-target-delta], genotype p < 0.001, event p < 0.001, interaction p < 0.001 [theta], rest p < 0.001, target p < 0.001 [WT-KO-theta], WT p = 0.014, KO p < 0.001 [rest-target-theta], genotype p < 0.001, event p < 0.001, interaction p = 0.002 [alpha], rest p < 0.001, target p = 0.039 [WT-KO-alpha], WT p = 0.331, KO p < 0.001 [rest-target-alpha], genotype p = 0.548, event p = 0.025, interaction p = 0.062 [gamma], rest p = 0.153, target p = 0.204 [WT-KO-gamma], WT p = 0.79, KO p = 0.004 [rest-target-gamma]). b Temporal changes in color-coded z-scores for spectral powers before and after sniffing (nose-poking) of S/O/E targets in WT and Shank2–/– mice. Z-scores were derived by normalizing powers in the time period around sniffing (nose pokes) to those during the rest period (see the “Methods” section for details on the z-score). c Changes in power spectral densities (PSD) before and after sniffing (nose pokes; −1.5 to −0.5 s and 0.5 to 1.5 s, respectively). Results for the gamma range are shown (n = 52 experiments from 5 WT mice, and 53 experiments from 5 KO mice, *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant, two-way ANOVA with Tukey’s test; time p = 0.441, target p = 0.009, interaction p = 0.031 [WT], pre p = 0.045, post p = 0.003 [E-S-WT], Empty p = 0.677, Social p = 0.258, object p = 0.023 [pre-post-WT], time p < 0.001, target p = 0.149, interaction p = 0.346 [KO], pre p > 0.05, post p > 0.05 [E-S-KO], Empty p = 0.003, Social p=0.005, Object p < 0.001 [pre-post-KO]). See Source data for raw data values and Supplementary Table 1 for statistical details.

Back to article page